Clinical signs of Hyperadrenocorticism (Cushing’s) include:
- Polydipsia (normal = 50-60 ml/kg/day).
- Polyuria (normal = 20-40 ml/kg/day).
- Polyphagia - often results in scavenging or stealing.
- Pot-belly - due to fat deposition, weakness of abdominal muscles and hepatomegaly.
- Thinning of the skin.
- Hair loss - cortisol has an inhibitory effect on the anagen growth phase of the hair cycle.
- Excessive panting.
- Neurological signs can occur with a large pituitary tumour.
The signs of Cushing’s syndrome arise due to an excess of circulating glucocorticoids, in particular cortisol which is produced by the adrenal cortex.